Echinacea contains sugars in its cell membrane which the body can build resistance to. Some believe that the immune system should not be constantly stimulated, and recommend not taking continuously (I.e. 8 weeks on, 1 week off). Alfalfa contains L-canavanine, which is suspected of causing some allergic reactions in susceptible people. Feverfew in large quantities is contraindicated with anticoagulant drugs (only a small amount is used in this synergistic formula). Kava kava should not be mixed with alcohol.
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