Thyroid hormones operate in a complex hormonal environment that includes multiple organs and hormones, along with neurotransmitters such as serotonin. Dr. Winifred Cutler, the biologist, calls this the "Hormonal Symphony." When thyroid hormones are low it affects sex hormones adversely, particularly progesterone, and can lead to estrogen dominance.
Sometimes hypothyroidism is caused by an autoimmune attack on the thyroid, where antibodies destroy important thyroid molecules. This is why it is important, in any thyroid support product, to include nutrition to support homeostasis and regulation of the immune system.
Ashwagandha: In pre-clinical trials, it was revealed that ashwagandha “stimulates thyroidal activity and also enhances the antiperoxidation of hepatic tissue hormone”, and that T-3 and T-4 (thyroxine), both thyroid hormones, were increased by ashwagandha (J Pharm Pharmacol. 1998 Sep;50(9):1065-8; J Ethnopharmacol. 1999 Nov 1;67(2):233- 9.) Ashwagandha has also been found to be a potent antioxidant that prevents lipid peroxidation, and hence damage of thyroid tissue due to oxidation. This can be really important when you consider that Hashimoto’s (autoimmune hypothyroidism) is a condition of antibody production that can be increased during oxidation/ damage of thyroid tissue (Pharmacol Res. 2000 Jun;41(6):663-6.) Ashwagandha “potently inhibits proinflammatory cytokines” (Drug Discov Ther. 2011 Aug;5(4):195-201.) Ashwagandha improves immune system function and leads to improved “haematological, biochemical and immunological parameters” when supplemented (Fish Shellfish Immunol. 2012 Mar 6.) It is believed that ashwagandha may even have neuroprotective benefits (Hum Exp Toxicol. 2005 Mar;24(3):137-47).
Larch Arabinogalactan is commonly used to support the immune system and also to support the thyroid. Larch is composed of greater than 98-percent arabinogalactan, making it an excellent source for this powerfully functional nutrient. It is an excellent source of dietary fiber, and has been approved as such by the FDA. It has been shown to increase the production of short-chain fatty acids, principally butyrate and propionate, and has been shown to decrease the generation and absorption of ammonia. Butyrate is the main fuel for large intestine cells. Evidence also indicates human consumption of larch arabinogalactan has a significant effect on enhancing beneficial gut microflora, specifically increasing Bifidobacteria and Lactobacillus (Altern Med Rev. 1999 Apr;4(2):96-103.) In a randomized, double-blind, placebo-controlled, prospective four-week clinical trial, arabinogalactan was found to possess immunomodulating properties (Altern Med Rev. 2007 Mar;12(1):25-48.)
Guggul Extract: NIEHS (a division of National Institutes of Health) reported in Feb 2005 that guggul extract (gum) is increasingly being used as a dietary supplement and that “biological effects have been demonstrated on lipid metabolism, thyroid hormone homeostatsis, female reproductive tissues, and endogenous nuclear hormone receptors” (they also reported “anti-inflammatory activity” in pre-clinical trials)
(Masten, SA., PhD. Gum Guggul and Some of Its Steroidal Constituents Feb. 2005. NTP/NIEHS Research Triangle Park, NC).
Guggul supplements are reported to help regulate thyroid function and improve hypothyroidism, according to pre-clinical trial studies (S. Panda et al. Phototherapy Research. January 2005; (Tripathi YB, et al. Thyroid stimulating action of Z- guggulsterone... Planta Med . 1984;50(1):78-80.) Dr. Richard B. Kreider, author of the book "Exercise and Sport Nutrition," also states that guggulsterones, found in guggul, have the ability to increase the output of the thyroid gland and stimulate the conversion of the T4 thyroid hormone into its more active T3 form (Exercise & Sport Nutrition: Principles, Promises, Science, & Recommendations; Richard B. Kreider et al.; 2009.) Increased T3 can help increase metabolism and burn fat. The University of Maryland Medical Center recommends 25 mg of guggulsterones three times daily to lower the high cholesterol levels associated with hypothyroidism.
Exciting research may be able to confirm that guggul naturally regulates a gene receptor called farnesoid X receptor (FSX) which controls metabolism in the liver.
The iodine molecule is needed for the synthesis of the thyroid hormones. In fact, three iodine molecules are added to the thyroid hormone T3 and four iodine molecules are added to T4. The fact that iodine insufficiency is rampant, coupled with the necessity of iodine to produce thyroid hormones contributes to widespread hypothyroidism.
Coleus Forskohlii raises cyclic AMP (which raises metabolism) in many systems, including endocrine tissues such as the thyroid gland by acting at a post-surface receptor site on the thyroid (Ealey PA, et al. (Acta Endocrinol (Copenh). 1985 Mar;108(3):367-71.) This increased metabolic rate is being researched for its effect on thermogenesis, weight management and thyroid function. Cyclic AMP and the chemicals it activates comprise a second messenger system that is responsible for carrying out complex and powerful effects of hormones in the body. The forskolin in coleus forskohlii is believed to stimulate secretion of T3 and T4 in a manner similar to TSH because of its effect on cyclic AMP (Venkateswaran A. et al. J Clin Endocrinol Metab. 2004 Dec;89(12):6168-72; Laurberg P.
Forskolin stimulation of thyroid secretion of T4 and T3. FEBS Lett. 1984 May 21;170(2):273-6; Hiraiwa M. Nippon Naibunpi Gakkai Zasshi. 1987 Jan 20;63(1):34-44) and also to stimulate iodine metabolism (iodine is needed to make thyroid hormones) (van Sande J, et al. Forskolin stimulates adenylate cyclase and iodine metabolism in thyroid. FEBS Lett. 1982 Dec 13;150(1):137-41.)
The following abstract points out that iodine is an antioxidant, that mg doses are safe (and effective) and that iodine has an important role in maintaining normal breast tissue as well as supporting the thyroid.
"Iodine deficiency is generally recognized as the most commonly preventable cause of mental retardation and the most common cause of endocrinopathy (goiter and primary hypothyroidism). Iodine deficiency becomes particularly critical in pregnancy due to the consequences for neurological damage during fetal development as well as during lactation. The safety of therapeutic doses of iodine above the established safe upper limit of 1 mg is evident in the lack of toxicity in the Japanese population that consumes 25 times the median intake of iodine consumption in the United States. Japan's population suffers no demonstrable increased incidence of autoimmune thyroiditis or hypothyroidism. Studies using 3-6 mg doses to effectively treat fibrocystic breast disease may reveal an important role for iodine in maintaining normal breast tissue architecture and function. Iodine may also have important antioxidant functions in breast tissue and other tissues that concentrate iodine via the sodium iodide symporter" (Patrick, L. Altern Med Rev. 2008 Jun;13(2):116-27.)
Ginseng has been traditionally used for thyroid support for many years. American Ginseng and Eleuthero (Siberian ginseng) are known as adaptogens and have been utilized traditionally for many years as thyroid support. An adaptogen is defined as an agent that helps to bring the body’s organ systems into homeostasis, whether function is high or low.
Selenium is a mineral that is absolutely essential for proper thyroid function. Selenium is highly concentrated in the thyroid gland, more so than in any other organ in the human body, indicating its role in normal thyroid function. It acts as an antioxidant that protects the thyroid gland, a cofactor nutrient that facilitates the production of thyroid hormone, and as a nutrient that is required to facilitate the conversion of T4 to T3 and also prevent the conversion of T3 into inactive, or reverse T3. Hypothyroidism can arise from many causes, however when the cause is an overabundance of reverse T3 many times the simple solution is providing enough selenium for this conversion.
L-Tyrosine is an amino acid that is crucial to thyroid hormone production. It is not only needed for thyroid hormone production, the tyrosine molecule is incorporated tight into the thyroid molecule. Tyrosine converts to dopamine and norepinephrine with the help of vitamin B6 and vitamin C. Norepinephrine is a neurotransmitter that can stimulate the hypothalamus and pituitary to activate the production of thyroid hormone (through TRH and TSH).
Yellow Dock is an herb which has practical applications in metabolism function, due to its high content of valuable minerals which affect thyroid health. Yellow Dock is a blood purifier that has a special synergistic function with iodine when it comes to the thyroid gland.
Gotu Kola has a long history of use in Ayurvedic medicine with many traditional indications. One of the indications for gotu kola is thyroid support. In addition to all of these synergistic herbs and nutrients, Total Thyroid #2 contains a blend of glandular support that ties in multiple organ systems that depend on each other to operate at full speed, including thymus, spleen, pituitary, adrenal and parotid.
Additionally, Total Thyroid #2 is packed full of the vitamins and minerals that together ensure optimal function of the thyroid gland, including: Vitamin B-1, Vitamin B-2, Vitamin B-6, Vitamin B-12, Vitamin A, beta carotene, Vitamin C, Niacin, Folic acid, Calcium, Manganese, Molybdenum and Zinc.
Contraindications: Check with your doctor if you are on thyroid medication. If supplementation increases thyroid activity it may be necessary to adjust the thyroid meds. Do not take with MAO inhibitors, blood thinners or in pregnancy.
Each Tablet Contains: Vitamin A (as palmitate)(1% as Beta Carotene) 505 IU, Vitamin C (as ascorbic acid) 50 mg, Calcium (as chelate) 25 mg, Thiamine (as hydrochloride) 5 mg, Riboflavin 5 mg, Niacin 2 mg, Vitamin B6 (as pyridoxine hydrochloride) 5 mg, Folate (as folic acid) 100 mcg, Vitamin B-12 (as methylcobalamin) 100 mcg, Iodine (as kelp, potassium iodide) 1530 mcg, Zinc (as chelate) 1.5 mg, Selenium (as methionine) 200 mcg, Manganese (as chelate) 0.800 mg, Molybdenum (as chelate) 30 mcg, Thymus (bovine) 40 mg, Spleen (bovine) 10 mg, Pituitary (bovine) 3 mg, Adrenal (bovine) 10 mg, Parotid (bovine) 3 mg, L-Tyrosine 50 mg, Choline (as bitartrate) 25 mg, Betaine (as hydrochloride) 25 mg, Ashwagandha Extract (root) 200 mg, Larch Arabinogalactan 100 mg, Guggal Extract (gum) 25 mg, American Ginseng (root) 20 mg, Eleuthero (root) 20 mg, Yellow Dock (root) 5 mg, Gota Kola (herb) 5 mg, Coleus Forskohlii Extract (root) 25 mg.
1 tablet daily or as directed.