This very powerful B vitamin combination formula supplies most of the B vitamins in their coenzymated forms so the body does not have to phosphorylate them, and includes our proprietary NatureFolate blend of active isomer naturally-occuring folates. TMG and choline were added to support methylation.
Product Contains: Vitamin B1 (as Thiamine HCl) 100 mg; Vitamin B2 50 mg;(as Riboflavin HCl 35 mg; Riboflavin-5-Phosphate 15 mg) Vitamin B3 50 mg (as Niacinamide); Vitamin B6 50 mg (as Pyridoxine HCl 40 mg; Pyridoxyl-5-Phosphate 10 mg); Folates (NatureFolateTM blend) 200 mcg; Vitamin B12 (as Methylcobalamin) 250 mcg; Biotin (as d-Biotin) 2 mg; Vitamin B5 (as Pantothenic Acid) 100 mg; Choline 200 mg; Trimethylglycine 200 mg;
Other Ingredients: Microcrystalline cellulose, magnesium stearate.
This product does not contain: wheat, yeast, soy, gluten, eggs, dairy, corn, artificial colors, flavors, sugars, or preservatives.
Serving Size: 1 Vegetarian Capsule
Recommended Use: As a dietary supplement, take one capsule per day with meals or as directed by your health care practitioner.
This powerful and effective B vitamin combination formula supplies B vitamins in their preferred coenzymated forms, where possible, so the body does not have to phosphorylate them in order to utilize them in biochemical reactions. B-Supreme also includes our proprietary NatureFolate(TM) blend of active isomer, naturally-occuring folates. Choline was added and TMG was increased to support efficient methylation for optimal genetic expression.
B vitamins are a family of water-soluble nutrients that were discovered together at the beginning of the 20th century, initially thought simply to be "vitamin B." As nutrition advanced, however, it was learned that they are in fact a family of compounds, each with a distinct role to play in promoting health. B vitamins are now known to play critical roles in modulating biochemistry and metabolism, and represent the most common vitamins utilized by the body as cofactors for facilitating enzymatic function. The modern refined diet, high in sugar, alcohol, and devitalized foods, leads to lower levels of B vitamins. Many medications and stress may lower B vitamin levels. While B vitamins have been for the most part researched individually, they also have therapeutic power when taken together. For example, a B complex supplement can relieve nocturnal leg cramps in the elderly.
Thiamin or Vitamin B1: Vitamin B1 is needed for energy production, heart function, and the health of the brain and nervous system. B1 also helps remove lead from the body. Fifty milligrams of B1 was given to sixty women for two months, and increased levels of B1 made these women feel more clearheaded, composed and energetic.2 Fifty milligrams of B1 per day improved mental wellness in epileptics.3 Twenty-five milligrams of thiamin with 50 mg of B6 leads to significantly reduced symptoms in patients with diabetic neuropathy.
Riboflavin (B2): Antioxidant and Migraine Preventer B2, also known as riboflavin, is another B vitamin that helps the body turn food into energy. B2 is also a powerful antioxidant. Riboflavin supplementation may help prevent migraine headaches. Patients with low thyroid function may have an increased need for vitamin B2, particularly in the activated form known as riboflavin-5-phosphate. Taking riboflavin imparts a yellow color to the urine which is harmless. Niacinamide: Antioxidant Aiding Glucose Control and Osteoarthritis Niacinamide is needed to metabolize food (carbohydrates, fats, and proteins) into energy. Niacinamide is converted into the coenzymes nicotinamide adenine dinucleotide (NAD) and NADP, which function in oxidation-reduction reactions. The liver can convert niacin into niacinamide by adding an amine group. Biological responses to niacin, nicotinic acid and niacinamide are virtually equivalent when taken in common doses. When taken in supra physiological doses they act differently (eg. 500 mg niacin for stabilizing lipids). Clinical signs of early niacinamide deficiency include lack of appetite, muscular fatigue, indigestion,depression, insomnia, headaches, glossitis, and skin lesions. Severe deficiency may lead to pellagra, with dermatitis, dementia, diarrhea (the "3 D's of pellagra), tremors and sore (black) tongue. Niacinamide may help those with osteoarthritis. One recent study of 72 osteoarthritis patients showed that niacinamide can improve joint flexibility, reduce inflammation, and allow for reduction in standard anti-inflammatory medications.6 Some people feel more relaxed when taking niacinamide. Niacinamide (also known as nicotinamide) has been shown in research to protect and even regenerate islet cells of the pancreas and may be helpful for prevention and control of Type 1 Diabetes.
*Due to some individuals having sensitivities with using even small doses of the other form of vitamin B3 niacin (or nicotinic acid), we have excluded this from our formula. For individuals seeking aggressive niacin therapy for the purpose of lowering lipids or for various circulatory disorders, you might consider our 500 mg Niacin CRT featuring our "Controlled Release Technology(TM)" which releases at a steady, controlled rate over 10-12 hours.
Vitamin B6: For Good Health - Vitamin B6 plays an important role in vital life processes, which include amino acid metabolism, hemoglobin production, the efficient functioning of the nervous and immune systems and the modulation of blood sugar.9 B6 supports overall female hormonal balance and is very useful in the management of PMS,10 as well as nausea and vomiting that may accompany pregnancy.11 The depression some experience on oral contraceptives can be helped with 40 mg per day of B6.12 A five month study with 76 asthmatics showed that 200 mg per day of B6 led to a reduction in the need for bronchodilators and asthmatic medications.13 Vitamin B6 has several forms, namely: pyridoxine, pyridoxal, pyridoxamine, and the phosphorylated versions of these forms. B6 in B-Supreme is presented as pyridoxine and the activated form known as pyridoxyl-5-phosphate.
Folate: For Wellness - Folates are essential cofactors in one carbon metabolism and their deficiency is associated with health risks such as neural tube defects, cancers and hyperhomocysteinemia. "Folic acid" and "folate" are often used interchangeably, but more appropriately, folic acid refers to the fully oxidized synthetic compound (pteroylmonoglutamic acid) used in dietary supplements and in food fortification.
NatureFolate(TM)Niacin and Niacinamide: Avoid both of these forms in high doses if you have jaundice, heart conditions including angina and rheumatic heart disease, ulcers, gastritis, renal failure, or gout. Vitamin B6: Do not take B6 with the drug levodopa, as it can inactivate it. Lactating women should not take more than 50 mg of B6 per day, as higher doses may suppress lactation. Folate: Avoid folate and folic acid supplements when taking the drug methotrexate for cancer.
Researchers at Designs for Health thoroughly reviewed hundreds of papers on folic acid and have decided that the fully oxidized, synthetic form is not the ideal choice for nutritional supplement formulations. DFH has replaced folic acid with a natural folate blend called NatureFolate(TM). NatureFolate(TM) is made from a concentrated vegetable juice powder containing a blend of natural folates, including 5-methyltetrahydrofolate (5-MTHF) and 5-formyltetrahydrofolate with additional fortified 5-formyltetrahydrofolate as calcium folinate.
Vitamin B12 is also available in activated forms such as methylcobalamin. Sixty milligrams of methylcobalamin was given every day for 6 months to 6 patients with chronic progressive MS. This led to improvement in abnormalities in both the visual and brainstem nerve function.14 Methylcobalamin may also be useful in the treatment of diabetic neuropathy, Bell's Palsy,15 and sleep-wake disorders.
Biotin: Strengthening Nails and Balancing Blood Sugar Biotin can help strengthen nails in humans by 25% in those with weak or brittle nails.16 A high intake of biotin can improve blood sugar control in animal models of type II diabetes. By helping keep blood sugar and insulin lower, biotin may support weight loss.17 Biotin may also help patients with diabetic neuropathy.18 Pantothenic Acid: For Stress and Wound Healing Pantothenic acid, previously known as vitamin B5, is a member of the B complex family that helps immune function, energy generation, and the body's production of stress hormones. Pantothenic acid may help those with rheumatoid arthritis, though more research is needed. B Vitamin Contraindications
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