Total Multimune for Supporting Immune System Strength

by

John Brimhall, D.C., and Stephan Cooter, Ph.D.

Go to Total Multimune Supplement (click here)

The thymus, parotid, lymph nodes, spleen, bone marrow, and tonsils all play essential roles in the body's immune system. Specialized white blood cells, lymphocytes, phagocytes, killer T-cells, antibodies, interferon, and lactoferrin also play major roles in immune function.

The immune system provides a first barrier defense against unfriendly microorganisms. The skin acts as a first barrier against unfriendly invasions.  Mucus secretions, including tears, gastric acid secretions, and saliva from the parotid gland, are also a part of this first line of defense.The adaptive-immune-system acquires immunity from infective viruses, bacteria, other microorganisms, and other toxins. Antibodies retain long term memories of all invaders it has faced, so that a person only has the mumps, for example, one time (Lininger, 1998:72-73).

Dietary habits can lower immune system function. All forms of refined sugar can interfere with the white blood cells abilities to destroy unfriendly bacteria (Sanchez, A, et al, "Role of sugars in human neutrophilic phagocytosis," Am J Clin Nutr 1973; 26:1180). Alcohol is reported to weaken a wide variety of immune responses (Ahmed, FE, "Toxicological effects of ethanol on human health," Crit Rev Tox 1995;25(4):347-67). Determining dietary allergies has been more helpful in resolving ear infections than conventional treatment with antibiotics. Infections simply disappear when the offending food is withdrawn (Pang, LQ, "The importance of allergy in otolaryngology," Clin Ecology 1982; 1(1):53). Excessive dietary fat has been reported to lower natural killer T-cell activity (Kubenna, KS, McMurray, DN, "Nutrition and the immune system: A review of nutrient-nutrient interactions," J of Am Diet Assoc 1996; 96(11):1156-64).

The immune system can also be depressed by stress, overwork, faulty sleeping, and the aging process (Lininger, 1998:73).

On the other hand, there are many lifestyle changes and dietary changes that can enhance immune system functioning. Exercise can increase natural killer T-cell activity, which helps prevent and fight infection (Nieman, DC, et al, "Physical activity and immune function in elderly women," Med Sci Sports Med 1993; 25(7): 823-31). Many vitamins, minerals, other nutrients, and phytochemicals alone and in combination can also boost immune system functioning.

Phytochemicals are not yet classified as nutrients, that is, substances essential for sustaining life, but they have been identified as containing properties for aiding in disease prevention. Phytochemicals are associated with the prevention or treatment of at least four of the leading causes of death in the United States: diabetes, cancer, cardiovascular disease, and hypertension Phytochemicals are involved in many processes that help prevent cell damage, prevent cancer cell replication, and decrease cholesterol levels (Bloch, A. et al,. "Position of the American Dietetic Association: Phytochemicals and functional foods," JADA 1995; 95: 493-496).

Protective phytochemicals are found abundantly in fruits and vegetables. Research has demonstrated that cancer is a largely avoidable and preventable disease. It has been estimated that more than two-thirds of cancer may be prevented through lifestyle modification alone. Nearly one-third of these cancer occurrences can be attributed to diet alone, secondary to the American diet of high-fat, low-fiber content. Fruit and vegetable consumption in population studies have been consistently shown to reduce the risk of many cancers and heart disease. The "5 A Day for Better Health" program sponsored by the National Cancer Institute encourages the public to include more fruits and vegetables in their diet, at least 5 servings a day (Oliveria, S. A. et al, "The Role of Epidemiology in Cancer Prevention," The Soc for Exp Bio and Med 1997; 216:142-150; Block, G. et al, "Fruit, vegetables, and cancer prevention: A review of the epidemiologic evidence," Nutr Cancer 1992;18:1-29).

TOTAL MULTIMUNE

Product # 2717 (90 tablet size)

Researched by and formulated for Dr. John Brimhall

Each tablet supplies: Vitamin A 750 i.u., Vitamin C 50 mg, Vitamin B-6 10 mg, Calcium (as chelate) 34 mg, Magnesium(as chelate)20 mg, Zinc (as chelate) 8 mg, Manganese (as chelate) 2 mg, IP6 (Inositol Hexaphosphate) 40 mg, Lycopene 2.5 mg, Colostrum 200 mg, Lymph 10 mg, Spleen 10 mg, Thymus 10 mg, Parotid 10 mg, Maitake Mushroom 30 mg, Green Tea Extract 20 mg, Astragalus 40 mg, Pomegranate (root) (with Ellagic Acid) 10 mg.

Recommendation: 1 tab 3 x day or as directed

Vitamin A [750 i.u.] is essential to a healthy immune system.  Without adequate vitamin A, microorganisms can penetrate the skin, lungs, and mucous membranes (Lininger, 1998:73). Vitamin A supplementation has helped vitamin A deficient children in coping with measles and other infectious diseases (Glasziou, PP, Mackerras, DEM, "Vitamin A supplementation in infectious diseases: A meta-analysis," BMJ 1993; 306:366-70). Vitamin A is necessary for the maintenance and repair of the epithelial tissues in the skin and mucous membranes that make up the body's first line of defense. Vitamin A protects against colds, influenza, and infections of the kidneys, bladder, lungs, and mucous membranes. Vitamin A acts as an antioxidant helping to protect cells against cancer and other diseases (Balch & Balch, 1998:13-14).

Vitamin C (50mg) has been reported to stimulate the immune system in part by elevating interferon activity, which may account for its antiviral activity (Gerber, et al, "Effect of ascorbic acid, sodium salicylate, and caffeine on serum interferon level in response to viral infection," Pharmacology 1975;13:228). Deficiency symptoms include poor healing time, bleeding gums, weakness, hemorrhages under the skin, increased susceptibility to infection, poor digestion, and tooth loss. Vitamin C is essential to tissue growth and repair and adrenal function. Vitamin C is reported to assist in the production of anti-stress hormones and interferon, to help prevent cancer, protect against infection, and enhance immunity (Balch & Balch, 1998: 18-19). Vitamin C enhances the activities of vitamin E. Vitamin C, with other free-radical scavengers, is reported to protect against cancer and to protect against cancer-causing nitrosamines (Mindell, 1991:43).

Vitamin B6 (10mg) is essential for the production of antibodies and red blood cells (Mindell, 1991: 33). B6 has been reported to help alleviate pains of palms and soles associated with the cancer-chemotherapy-agent, Fluoracil's effects (Vukelja, SJ, et al, "Pyroxidine [sic] for the palmar-plantar crythrodysesthesia syndrome," Ann Intern Med 1989; 111:688-89).

Calcium (as chelate) [34mg] is essential for cellular metabolism and protects against colon cancer (Slattery, et al, "Dietary calcium intake as a mitigating factor in colon cancer," Am J of EpidemiolSept 1988; 128(3): 504-14).

Magnesium (as chelate) [20mg] helps maintain the pH balance of blood and tissue, helps in the synthesis of RNA and DNA, and has been reported to protect against cancer in general (Blondell, JM, "The anticarcinogenic effect of magnesium,"Med Hypotheses Aug 1980; 6(8):863-71).

Zinc (as chelate) [8mg] supplementation has been demonstrated to increase immune function and enhance lymphocyte activity (Duchateau, J, et al, "Influence of oral zinc supplementation on the lymphocyte response to mitogens of normal subjects," Am J Clin Nutr 1981; 34: 88-93; Fraker, PJ, et al, "Interrelationships between zinc and immune function," Fed Pro 1986; 45:1474-9). Zinc is an antioxidant and plays a role in the synthesis of the antioxidant enzyme SOD. Zinc is necessary to maintain vitamin E levels and assists in the absorption of vitamin A. Zinc also participates in the promotion of glandular, reproductive, and immune system health (Balch & Balch, 1997: 45-46). Zinc lozenges are reported to reduce the severity of symptoms in the common cold and to reduce the duration of the infection (Lininger, 1998:73). Zinc is one of four minerals known to stimulate the release of Human Growth Hormone. Zinc is essential for the body's protein synthesis, regulates the contraction of muscle, and is important in the formation of insulin. Zinc has been reported to accelerate healing time, eliminate taste loss, promote growth, and mental alertness (Mindell, 1991: 112, 94).

Manganese (as chelate) [2mg] is essential in the formation of thyroxin by the thyroid gland and is necessary in activating enzymes for the body's use of vitamin C, biotin, and vitamin B1 (Mindell, 1991:83). Manganese helps maintain cellular integrity (The Burton Goldberg Group, 1995:392).

IP6 (Inositol hexaphosphate) [40mg] has been reported to boost the immune system's natural killer cells, called lymphocytes. IP6 is a powerful antioxidant naturally present in whole grains and high fiber foods such as whole kernel corn and beans. IP6 is known to prevent blood clots and platelet stickiness, a major cause of heart attacks and strokes, as well as reduce cholesterol and fatty acids in the blood stream. It is reported to be helpful in preventing kidney stones and preventing accumulation of fatty deposits in the liver. Population studies show the people who consume diets high in IP6 also show a lower incidence of colon, breast, and prostate cancers. IP6 supplementation in combination with inositol has been reported to show visible signs of tumor regression (Pirisi, A, "Health Brief, IP6, This potent antioxidant can help your body fend off cancer and heart disease," Natural Health March 1999: 138). Caution: Supplemental IP6, unlike IP6 found in whole grains, has been found to interfere with the body's absorption of minerals. If you take this supplement, do not take the supplement within one hour of meals.

Lycopene (2.5mg) is a member of the carotene family, including beta carotene, found principally in tomatoes and tomato products. Lycopene has potent antioxidant capabilities. Of the carotenes investigated in one Harvard study, the men who had the greatest amount of lycopene showed a 21% decreased risk of prostate cancer.  Lycopene has also been shown to be a more potent inhibitor of cancer cells than other carotenoids. For 25% of the people with the greatest tomato intake, the risk for cancers of the GI tract was 30-60% lower than those who ate fewer tomatoes (Giovannucci, E, et al, "Intake of carotenoids and retinol in relation to risk of prostate cancer," JNCI 1995; 87: 1767-76; Francesci, S, et al, "Tomatoes and the risk of digestive tract cancers," Int J Cancer 1994;59:181-84).

Colostrum (200mg) is produced for 3 days after giving birth in female mammals. Colostrum contains numerous factors that foster the development of a strong immune system including antibodies, which protect infants against pathogens. Mother's milk contains antibodies to all diseases the mother has contacted before her pregnancy, with the exception of antibodies from vaccines. Colostrum has been reported to modulate the immune system: it can boost an underactive immune system and suppress an overactive one. Colostrum studies demonstrate that supplemental colostrum protects adults from pathogens that occur or enter the digestive tract and the benefits transfer between species. Colostrum also contains an abundance of vitamins, minerals, enzymes, and immune factors that are beneficial to adults as well as infants that enhance digestion and metabolism. The second most abundant protein in colostrum is lactoferrin (Ley, BM, Colostrum: Nature's Gift to the Immune System. Donatello, Aliso Viejo, CA: BL Publications, 1997).

Lymph (10mg): Lymph is a plasma like fluid composed of lymphocytes, special white blood cells also found in the spleen, thymus gland, bone marrow, and gut wall. These lymphocytes are made up of B-lymphocytes and T-lymphocytes, which help identify "self" cells, or healthy cells, and "non-self" cells, and bind with foreign invaders, worn-out, damaged, or diseased cells. Other lymphocytes are called cytokines, which include Tumor Necrosis Factor. T-lymphocytes originate in bone marrow and migrate to the thymus where they mature, learning to identify self and non-self, and to acquire repertoires, as helper cells for other parts of the immune system or killer cells against cells and invaders that threaten self (Merck Manual1992: 279-88). Glandular nutrients such as lymph are believed to help repair damaged, deteriorated, or auto-immune system attacks on aging and malfunctioning glands and help restore them to normal activity, based on the work of Dr. Royal Lee (Balch & Balch,1997: 551-552; Lee, R, "The control of growth, health and vitality by protomorphogens," Vitamin News May 1954: 195-6).

Spleen (10mg): The spleen helps produce and store B-lymphocytes and T-lymphocytes, our antibodies which identify toxins and damaged, worn out cells, and phagocytes, which help digest and remove worn-out cells and foreign toxins (Merck Manual, 1992: 1259). Glandular nutrients such as spleen are used to provide nutrition to support the healthy and proper functioning of the gland. Glandular nutrients are also believed to help repair damaged, deteriorated, or auto-immune system attacks on aging and malfunctioning glands and help restore them to normal activity, based on the work of Dr. Royal Lee (Balch & Balch,1997: 551-552; Lee, R, "The control of growth, health and vitality by protomorphogens," Vitamin News May 1954: 195-6).

Thymus (10mg): The thymus generates T- (Thymus-derived) cells. In infancy, the thymus is largest and continues to grow into puberty, when it begins to shrink. In early life, it is the main controller of the immune response. In later life, it is a schoolroom-mediator where lymphocytes learn roles in identifying antibodies, as messengers for the immune system, as killer cells, and as helper cells. Some killer cells recognize and target foreign toxins; others recognize and target tumor cells (Merck Manual, 1992:279-87). Glandular nutrients such as thymus are believed to help repair damaged, deteriorated, or auto-immune system attacks on aging and malfunctioning glands and help restore them to normal activity, based on the work of Dr. Royal Lee (Balch & Balch,1997: 551-552; Lee, R, "The control of growth, health and vitality by protomorphogens," Vitamin News May 1954: 195-6).

(10mg): The parotid is one of 3 sets of salivary glands. Saliva is part of the body's first line of defense for anything entering the mouth and alimentary tract. It produces a number of defensive polypeptides, defensins, and lactoferrin, an iron binding glycoprotein, that blocks unfriendly bacteria from obtaining a source of iron, so they die. Lactoferrin is also found in the products of all exocrine glands located in the gateways of the digestive, respiratory, and reproductive systems, in saliva, tears, nasal secretions, and seminal plasma. In blood, lactoferrin is derived from a special group of white blood cells, the neutrophils. Lactoferrin has also been reported to stimulate the immune system, to have both antibacterial and antiviral properties, to promote protective flora in the gut,to help regulate iron metabolism, and to help prevent harmful oxidation. Saliva also contains digestive enzymes, which begin the digestion of starches, and bathe the teeth in alkaline mineral nutrients (Levay, PF, Viljoen, M, "Lactoferrin: a general review," Haemotologica 1995; 80:252-67; Reiter,B, "The biological significance of the non-immunoglobulin protective proteins in milk," in Developments in Dairy Chemistry, vol 3, 1985: 281-336).

Maitake Mushroom (30mg) contains 1,3 beta D-glucans, which constitute 10-50% of its dry weight. Kurashige, SY, et al, (1997) and Okasaki, et al, (1995) demonstrated that Beta glucans stimulated cytokine production from macrophages triggering an enhanced immune response ("Effects of Lentius edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosamine," J of Immunopharm and Immunotox May 1997;1902:175-183; "Structure-activity relationship of (1-3) beta-D-glucans in the induction of cytokine production from macrophages in vitro," Biol & Pharm Bull Oct 1995; 18(10):1320-7). Many Japanese studies show that maitake constituents can exhibit direct anti-tumor activity especially in breast and colorectal cancer, but also in liver and lung cancer patients. Beta-glucans polysaccharides have also been reported to stimulate Tumor Necrosis Factor, and to be a possible treatment for diabetes by lowering and moderating glucose levels. They are presently the subject of investigation in the treatment of HIV patients (Stamets, P, Wu Yao, D, "Mycomedicinals, Information on medicinal mushrooms," Townsend LfD&P June 1998; 151-69). Maitake has been reported supportive in chemotherapy, increasing the success of chemotherapy, and other conditions involving weakened immune systems (Lininger, 1998:288, 72, 25).

Green Tea Extract (20mg) has been reported to stimulate the production of immune cells and has been demonstrated to have antibacterial properties (Stoner, GD, Mukhtar, H, "Polyphenols as cancer therapeutic agents," J Cell Bioch 1995; 22: 169-80; Hamilton-Miller, JM, "Antimicrobial properties of tea (amellia sinensis L.)," Antimicrob Ag Chemo 1995; 39(11):2375-77). Green tea contains volatile oils, vitamins, minerals, and caffeine, but the active ingredients are polyphenols, especially the catechin called epigallocatechin gallate. These polyphenols are believed to be responsible for green tea's role in promoting good health. Green tea helps protect cardiovascular health by improving the cholesterol profile, reducing platelet aggregation, and lowering blood pressure. The polyphenols have been reported to stimulate several immune system cells and to have antibacterial properties (Graham, HN, "Green tea composition, consumption, and polyphenol chemistry," Prev Med 1992; 21:334-50; Yamguchi, Y, et al, "Preventive effects of green tea extract on lipid abnormalities in serum, liver, and aorta of mice fed an atherogenic diet," Nip Yak Zas 1991; 97(6):329-37; Stensvold, I, et al, "Tea consumption. Relationship to cholesterol, blood pressure, and coronary and total mortality," Prev Med 1992; 21:546-53; Hamilton-Miller, JM, "Antimicrobial properties of tea (Camellia sinensis L.), Antimicro Ag Chemo 1995; 39(11): 2375-77).

Astralagus (40mg) has been reported to have immune-potentiating actions. According to research conducted at M.D. Anderson Hospital in Houston, Texas, astralagus was reported to restore T-cell counts to relatively normal ranges in some cancer patients (Lininger, 1998: 234).

Astralagus contains numerous phytochemicals and nutrients including flavonoids, polysaccharides, triterpene glycosides, amino acids and trace minerals (Shuy, HY, Oriental Materia Medica: A Concise Guide, Palos Verdes, CA: Oriental Healing Arts Press, 1992: 27-33).

Shen Nong, the founder of Chinese herbal medicine, classified astralagus as a superior herb and one of the most important tonic herbs in his classical treatise, Shen Nong Pen Tsao Ching, A.D., circa 100. Traditional Chinese medicine used this herb for treatment of deficiency of chi, for example, fatigue, weakness, loss of appetite, also for diarrhea, and night sweats (Foster, S, Chongxi, Y, Herbal Emissaries: Bringing Chinese Herbs to the West, Rochester, VT: Healing Arts Press, 1992:27-33). Astralagus has been reported supportive for immune function, viral infections, chemotherapy patients, and Alzheimer's disease (Lininger, 1998:233).

Pomegranate (root) (with Ellagic Acid) [10mg]: Ellagic Acid is the major phytochemical constituent of pomegranate and has been reported to be important for its protective effect as an antimutagen, anticarcinogen, and its role in helping with chemically induced cancers. Ellagic acid induces glutathione S-transferase enzymes, which help detoxify carcinogens and help reduce tumorigenesis. Studies have shown the use of ellagic acid resulted in a 44-75% reduction in lung tumors, and some reduction of liver, skin, and esophagus cancers in rodents. Ellagic acid has been shown to be a very powerful scavenger of free radicals activated by tobacco smoke, food additives, and petroleum substances.

Ellagic acid has been reported to inhibit the activation of carcinogens, to detoxify carcinogens by stimulating glutathione s-transferase, to bind with carcinogens and help construct harmless compounds incapable of damaging healthy DNA, and to prevent damaging substances from entering healthy DNA.

Lower concentrations of ellagic acid have been shown to slow the growth of cancer cells. Higher concentrations have been reported to kill cancer cells.

There are worldwide studies on bioavailability of the polyphenols, ellagic acid, ellagic tannins, and gallic acid taken from various sources like pomegranate, strawberries, raspberries and walnuts for their effectiveness as protective phytochemicals against cancers.

 Ellagic acid and some ellagitannins have shown inhibitory properties against replication of human immunodeficiency viruses (HIV) (Asanaka et al., 1988; Take et al., 1989). Ellagic acid also has been found to control hemorrhage in animals and humans. It also may have some blood pressure lowering effects and sedative effects according to preliminary research with rodents (Stoner, GD, Hasan, M, "Polyphenols as cancer chemopreventive agents," J of Cell Biochem 1995:22:169-180; Maass, JL, Galletta, GL, "Ellagic acid, an anticarcinogen in fruits: A review," a reprint from Hortscience January 1991; 26(1):N.P.).

Ellagic acid exhibits potent anti-oxidant effects. This properly coupled with its other effects, it has been reported to make it an effective chemopreventative against both the initiation and the promotion and progression stages of carcinogenesis (Cozzi, R, et al, "Taurine and ellagic acid: two differently acting natural antioxidants," Environ Mol Mutagen 1995; 26(3):248-54).

 

References

Balch JF, and PA Balch, Prescription for Nutritional Healing, 2nd Edition, New York: Avery, 1997.

Berkow R, The Merck Manual, 16th Ed., Rathway NJ: Merck Research Laboratories, 1992.

The Burton Goldberg Group, Alternative Medicine, The Definitive Guide, Fife, Washington: Future Medicine Publishing, Inc., 1995

Lininger S, Wright J, Austin S, Brown D, Gaby A, The Natural Pharmacy, Rocklin, CA: Prima Health, 1998.

Mindell E, Earl Mindell's Vitamin Bible, New York: Warner Books, 1991.

Rector-Page, L, How to be Your Own Herbal Pharmacist, An Herbal Formula Reference, N.G., 1991.

Stoner GD, et al, "The dietary anticancer agent ellagic acid is a potent inhibitor of DNA topoisomerases in vitro," Nutr Cancer 1995; 3(2):121-30.

Tierra M, The Way of Herbs, With the Latest Developments in Herbal Science, New York: Pocket Books, 1990.


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